| Autor: |
Coker DD, Elias EG, Chretien PB, Gray WC, Coleman JJ, Zentai TA, Didolkar MS, Morris DM, Viravathana T, Hebel JR |
| Jazyk: |
angličtina |
| Zdroj: |
Head & neck surgery [Head Neck Surg] 1981 Nov-Dec; Vol. 4 (2), pp. 111-7. |
| DOI: |
10.1002/hed.2890040205 |
| Abstrakt: |
Fifty-one patients (32 previously untreated, 19 previously treated) with advanced squamous cell carcinoma of the head and neck received a single course of combination chemotherapy consisting of high dose cis-platinum (DDP), bleomycin (Bleo), +/- high dose methotrexate (MTX). Thirty-three (65%) patients responded to therapy; 5 (10%) of these patients had a complete response. Previously untreated patients and those who received the three drugs (DDP, Bleo and MTX) had the highest response rates. The duration of response was 8 to 12 weeks. Seven (15%) patients showed a two-year survival rate. All nonresponders were dead of disease within two years. Three (56%) of the five complete-response patients and 4 (21%) of the partial-response patients survived for two years. The role of preoperative chemotherapy in head and neck cancer is yet to be conclusively defined. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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