| Autor: |
Mentkevich LM, Churbakova EV |
| Jazyk: |
ruština |
| Zdroj: |
Voprosy virusologii [Vopr Virusol] 1981 Jul-Aug (4), pp. 410-4. |
| Abstrakt: |
Mouse peritoneal macrophages produce two types of interferon: type 1 interferon resistant to pH 2.0 is produced in response to the inoculation of virus and poly(I) . poly(C), type 2 interferon (immune), sensitive to pH 2.0 is induced by phytohemagglutinin and is formed due to phagocytosis of sheep erythrocytes treated with specific antiserum. The virus-induced interferon is produced by macrophages very rapidly (maximum within 1-2 hours), and the antiviral state resulting from it develops within 1-3 hours after inoculation of the inducer. Immunization of mice as well as pretreatment of macrophages with small doses of interferon did not affect their interferon-synthesizing activity. Type 2 interferon produced a marked antiproliferative effect in L cell culture. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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