| Autor: |
Xiao-Chang F, Uehara Y, Abe Y, Hori M, Hamada M, Umezawa H |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of antibiotics [J Antibiot (Tokyo)] 1981 Jun; Vol. 34 (6), pp. 713-8. |
| DOI: |
10.7164/antibiotics.34.713 |
| Abstrakt: |
A new derivative of rifamycin SV, R-75-1, inhibits RNA synthesis in Mycobacterium smegmatis ATCC 607 (M607) at a concentration 10 times lower than rifampicin (RFP). However, both R-75-1 and RFP inhibit RNA polymerase reaction by 50% at the same concentration level (0.05 approximately 0.1 microgram/ml). Both inhibit the initiation process of RNA synthesis. E. coli RNA polymerase of the RFP-resistant strain was resistant to R-75-1. RFP was not inactivated by M607 cell extracts. The inhibitory effect of R-75-1 is markedly diminished if mycobacteria are grown in the medium containing Tween 80. On the basis of these results, the greater activity of R-75-1 to mycobacteria is suggested to be due to the better permeability than RFP. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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