| Autor: |
Spencer KM, Tarn A, Dean BM, Lister J, Bottazzo GF |
| Jazyk: |
angličtina |
| Zdroj: |
Lancet (London, England) [Lancet] 1984 Apr 07; Vol. 1 (8380), pp. 764-6. |
| DOI: |
10.1016/s0140-6736(84)91278-9 |
| Abstrakt: |
Complement-fixing islet-cell antibodies (CF-ICA) were found in 20 out of 685 unaffected first-degree relatives of children with type 1 diabetes. During a 5-year follow-up, 7 of the 20 became diabetic, 1 continued to show the antibodies without any abnormality of glucose tolerance, and 12 subjects lost them without the disease developing. Although CF-ICA are useful as a marker of active insulitis they should not at present be used to define subjects who might benefit from preventive immunosuppression. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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