| Autor: |
Trybulski EJ, Benjamin LE Sr, Earley JV, Fryer RI, Gilman NW, Reeder E, Walser A, Davidson AB, Horst WD, Sepinwall J, et. al. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1983 Nov; Vol. 26 (11), pp. 1589-96. |
| DOI: |
10.1021/jm00365a008 |
| Abstrakt: |
A series of 5H-pyrimido[5,4-d][2]benzazepines has been synthesized, starting from the corresponding 2-benzazepin-5-ones, and evaluated as potential anxiolytic agents. Selected compounds from this series show a pharmacological profile of action different than that of diazepam. They are more potent than diazepam in the anti-pentylenetetrazole test and in the [3H]diazepam binding assay, yet show less activity in the inclined screen test. A pharmacological data profile is given for 9-chloro-7-(2-chlorophenyl)-5H-pyrimido[5,4-d] [2]benzazepine (7c). The structure-activity relationships of these potential anxiolytic agents are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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