| Autor: |
Ritter MA, Sauvage CA, Delia D |
| Jazyk: |
angličtina |
| Zdroj: |
Immunology [Immunology] 1983 Jul; Vol. 49 (3), pp. 555-64. |
| Abstrakt: |
Human Thy-1 is present on the surface of only a small proportion of haemopoietic cells (thymus--0.2-10%; bone marrow--0.1-0.5%). We have analysed these Thy-1+ cells in more detail using immunofluorescence on a wide range of human haemopoietic cell lines and fresh leukaemic blasts; both situations where rare cells can become clonally expanded. The data demonstrate that Thy-1 is confined to the early stages of T- and B-lymphocyte development, and is absent from all myeloid cells. The Thy-1+ B cells represent late pre-B (c mu+)/early sIgM+ B cells. The Thy-1+ T cells are situated in the outer thymic cortex. Dual immunofluorescence analysis of FACS separated Thy-1+ thymocytes shows them to have the antigenic phenotype and morphology of prothymocytes/early thymocytes (some overlap seen with CALLA, TdT, OKT6 and OKT1). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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