| Autor: |
Patt HM, Maloney MA, Flannery ML |
| Jazyk: |
angličtina |
| Zdroj: |
Experimental hematology [Exp Hematol] 1982 Oct; Vol. 10 (9), pp. 738-42. |
| Abstrakt: |
Autologous fibroblast derivatives of red and yellow marrow of rabbits were shown to differ in their capability to transfer a hematopoietic microenvironment upon implantation under the renal capsule. Although a heterotopic ossicle formed in each instance, the quality of the associated medullary tissue mirrored the quality of the bone marrow used to generate the stromal fibroblasts. Thus, fibroblasts cultured from a cellular marrow produced a stroma with numerous hematopoietic foci whereas those cultured from a severely hypocellular marrow produced a stroma with mainly fat cells. The results with 21 implants point to a transmittable regulatory role of a class of stromal fibroblasts. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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