| Autor: |
Tonew M, Tonew E, Indulen MK, Dzeguze DR, Oehring H, Schmidt J |
| Jazyk: |
angličtina |
| Zdroj: |
Acta virologica [Acta Virol] 1982 May; Vol. 26 (3), pp. 130-6. |
| Abstrakt: |
Some hetarylhydrazones showed antiviral activity against Mengo virus in vitro. The replication of influenza A and B viruses was affected neither in vitro (chick chorioallantoic membranes) nor in vivo (mice). Based on dose response curves of the active hetarylhydrazones the compound Z 98/69 appeared most effective in vitro. This compound neither inactivated the extracellular virus nor inhibited its adsorption and penetration; it reduced virus replication when added 1-3 hr after Mengo virus inoculation. As shown by plaque reduction test vaccinia virus was also inhibited. A partial inhibition of rhinovirus 1B multiplication was observed whereas other picornaviruses were not affected. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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