| Autor: |
Innemee HC, de Jonge A, van Meel JC, Timmermans PB, van Zwieten PA |
| Jazyk: |
angličtina |
| Zdroj: |
Naunyn-Schmiedeberg's archives of pharmacology [Naunyn Schmiedebergs Arch Pharmacol] 1981 Jul; Vol. 316 (4), pp. 294-8. |
| DOI: |
10.1007/BF00501360 |
| Abstrakt: |
The influence of topically applied selective alpha 1-and alpha 2-adrenoceptor agonists on intraocular pressure and the diameter of the pupil was investigated in conscious rabbits. Selective stimulation of the alpha 1-subtype of receptors induced an elevation in intraocular pressure, accompanied by mydriasis, whereas stimulation of the alpha 2-subtype caused a marked and dose-dependent ocular hypotensive response, which was blocked by the selective alpha 2-adrenoceptor antagonist yohimbine. alpha 2-Agonists induced neither macroscopic ocular side effects, nor an effect on the pupil size. Possibly, the subclass of alpha 2-adrenoceptor stimulating drugs represents a group of new antiglaucomatous agents. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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