Human glucagon-like peptides 1 and 2 activate rat brain adenylate cyclase.

Autor: Hoosein NM, Gurd RS
Jazyk: angličtina
Zdroj: FEBS letters [FEBS Lett] 1984 Dec 03; Vol. 178 (1), pp. 83-6.
DOI: 10.1016/0014-5793(84)81245-4
Abstrakt: Two human glucagon-like peptides, GLP-1 and GLP-2, which are coencoded with pancreatic glucagon in the preproglucagon gene, do not significantly inhibit [125I]monoiodoglucagon binding to rat liver and brain membranes and do not activate adenylate cyclase in liver plasma membranes. Nevertheless, GLP-1 and GLP-2 were each found to be potent stimulators of both rat hypothalamic and pituitary adenylate cyclase. Only 30-50 pM concentrations of each peptide elicited half-maximal adenylate cyclase stimulation. Our data suggest that GLP-1 and GLP-2 may be neurotransmitters and/or neuroendocrine effectors, which would account for their high degree of sequence conservation through vertebrate evolution.
Databáze: MEDLINE