| Autor: |
Ali M, Zamecnik J, Cerskus AL, Stoessl AJ, Barnett WH, McDonald JW |
| Jazyk: |
angličtina |
| Zdroj: |
Prostaglandins [Prostaglandins] 1977 Nov; Vol. 14 (5), pp. 819-27. |
| DOI: |
10.1016/0090-6980(77)90299-4 |
| Abstrakt: |
Bovine gastric mucosal microsomes synthesize prostaglandins from arachidonic acid but thromboxane B2 is the principal product. Thromboxane B2 synthesis occurs at an appreciable rate from endogenous precursor but more rapidly with added arachidonate. Nonsteroidal antiinflammatory drugs inhibited synthesis of prostaglandins and thromboxanes with the following decreasing order of potency: indomethacin, fenoprofen, acetylsalicylic acid, phenylbutazone, sulfinpyrazone, and acetaminophen. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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