Metabolic effects of clofibrate on experimental animals.

Autor: Bedö M, Kramer M, Blaskovits A, Gefferth G, Tarjan R
Jazyk: angličtina
Zdroj: Arzneimittel-Forschung [Arzneimittelforschung] 1978; Vol. 28 (7), pp. 1076-80.
Abstrakt: The effect of ethyl-alpha-(p-chlorophenoxy)-isobutyrate (clofibrate, Miscleron) on certain parameters of lipid and carbohydrate metabolism was studied in male and female white rats. The vitamin A content and the mixed function oxydase activity in the liver was also examined. 1. In short-term experiments over 10 to 30 days clofibrate significantly influenced the examined parameters. In a long-term experiment (9 months), however, these changes were no more observable. 2. Clofibrate exerted a protective effect against lipid mobilization following physical exercise (swimming). 3. No significant differences between male and female rats after clofibrate treatment could be observed.
Databáze: MEDLINE