| Autor: |
Aberg G, Dhunér KG, Sydnes G |
| Jazyk: |
angličtina |
| Zdroj: |
Acta pharmacologica et toxicologica [Acta Pharmacol Toxicol (Copenh)] 1977 Nov; Vol. 41 (5), pp. 432-43. |
| DOI: |
10.1111/j.1600-0773.1977.tb02153.x |
| Abstrakt: |
When the number of carbon atoms on the piperidine-nitrogen of the mepivacaine molecule was increased up to four or five carbons, the toxicity of the compounds and the duration of their local anaesthetic effects were increased. With longer N-alkyl-chains, the general toxicity and the local anaesthetic potency - but not the tissue toxicity - were reduced. In dental infiltration anaesthesia only the short-chain compounds offered an acceptable local anaesthesia. In these tests, the medium-chain compounds had a very unfavourable quotient between dental anaesthesia and soft tissue anaesthesia, while the long-chain compounds could not be tested at all in man because of their tissue irritating properties. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text