| Abstrakt: |
The effect of certain amino acids on transformation of glucoseoxidase as an antigen in different tissues of the animals immunized with it showed that the used glucoseoxidase of the fungus Penicillium vitale Pidopl. et Bilaj possesses antigenic properties peculiar to this enzyme isolated from other sources. 1.5 minutes after a single administration of the antigen to nonimmunized rabbits it is determined in them in descending amounts in such an order: blood, lungs, liver, kidneys, lymphatic nodes. The same order is for immunized animals, but the enzyme quantity 1.5 minutes after the last injection is lower considerably in the kidneys, spleen, lymphatic nodes and in blood serum and changes slightly in the lungs and liver. The preliminary loading of animals under experiment immunized with amino acids accelerates essentially disappearance of the antigen under determination (glucoseoxidase in the given case) in the studied tissues. The data obtained testify to the fact that acceleration of antigen disappearance may be not related to interaction with antibodies. |
