| Autor: |
Aoki T, Kvedar JP, Hollis VW Jr, Bushar GS |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of the National Cancer Institute [J Natl Cancer Inst] 1976 Mar; Vol. 56 (3), pp. 687-90. |
| DOI: |
10.1093/jnci/56.3.687 |
| Abstrakt: |
An inactivated and lyophilized preparation of a low virulence strain (Su) of Streptococcus pyogenes (group A) was designated OK-432. When 2- and 5-month-old AKR mice were inoculated im with OK-432 twice weekly throughout their life-spans, spontaneous leukemias occurred later and at a lower incidence than in control groups. By virus neutralization and cytotoxicity tests and by immunoelectron microscopy, antibodies against virus and cell-surface antigens of transplanted AKR leukemia were not detectable in sera of nonleukemic mice of any group. Whereas sera from mice treated with OK-432 were the only positive for interferon, viremia was clearly demonstrated in control groups by reverse transcriptase assays of the plasma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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