Allylic esters as potential antitumor agents. Derivatives and analogues of 2,3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene.
| Autor: | Anderson WK, Dewey RH, Mulumba B |
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| Jazyk: | angličtina |
| Zdroj: | Journal of medicinal chemistry [J Med Chem] 1979 Oct; Vol. 22 (10), pp. 1270-2. |
| DOI: | 10.1021/jm00196a024 |
| Abstrakt: | Derivatives and analogues of 2,3-bis(hydroxymethyl)-7-oxabicyclo[2.2.1]hept-2-ene were synthesized. Of the compounds prepared, dimethyl 2,3-bis(acetoxymethyl)-7-oxabicyclo[2.2.1]hepta-2,5-diene-5,6-dicarboxylate (5) was the most potent in a leukemia L1210 tissue culture assay (93% inhibition at 10(-6) M). None of the compounds showed significant reproducible in vivo antileukemic activity. |
| Databáze: | MEDLINE |
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