| Autor: |
Sheth UK, Paul T, Desai NK, Pispati PK |
| Jazyk: |
angličtina |
| Zdroj: |
British journal of clinical pharmacology [Br J Clin Pharmacol] 1979 Nov; Vol. 8 (5), pp. 475-8. |
| DOI: |
10.1111/j.1365-2125.1979.tb01029.x |
| Abstrakt: |
1 Imipramine induced significant reduction in salivary rate compared to placebo in a cross-over, double-blind study of twelve normal volunteers. In contrast, there was no significant difference between the reduction in salivary rate induced by dothiepin and placebo. 2 Comparison of salivary rates showed no significant difference between the drugs in the initial and cross-over treatment periods. However, pooled observations from the initial and cross-over treatment periods indicated that imipramine produced a significantly greater reduction in salivary rate than dothiepin. 3 The results suggest that dothiepin would cause far less dryness of mouth compared to imipramine. This feature might ensure greater therapeutic compliance. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text