| Autor: |
Welstead WJ Jr, Moran HW, Stauffer HF, Turnbull LB, Sancilio LF |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of medicinal chemistry [J Med Chem] 1979 Sep; Vol. 22 (9), pp. 1074-9. |
| DOI: |
10.1021/jm00195a012 |
| Abstrakt: |
The synthesis and antiinflammatory activity of 2-amino-3-benzoylphenylacetic acid are described. This compound was postulated to be an active metabolite of 7-benzoylindoline in order to explain the unexpected antiinflammatory activity of the latter compound. Metabolism studies on 14C-labeled 7-benzoylindoline did not confirm this hypothesis. Nevertheless, 2-amino-3-benzoylphenylacetic acid, its ethyl ester, and the sodium salt show potent antiinflammatory activity in pharmacological models. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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