| Autor: |
Innemee HC, van Zwieten PA |
| Jazyk: |
angličtina |
| Zdroj: |
Documenta ophthalmologica. Advances in ophthalmology [Doc Ophthalmol] 1979 Mar 15; Vol. 46 (2), pp. 309-15. |
| DOI: |
10.1007/BF00142620 |
| Abstrakt: |
In order to study the influence of clonidine on intraocular pressure (IOP), the drug was administered via different routes. The experiments were performed on chloralose-anaesthetized cats. The rise in IOP observed after administration of clonidine into the external carotid arteries was subjected to a pharmacological analysis. Our experiments suggest that the increase in IOP is due to the contraction of eyelids and extraocular muscles, mediated by the influence of clonidine on alpha-adrenoceptors. The IOP-lowering effect of clonidine was more pronounced after its infusion into the left vertebral artery than after its intravenous injection. This difference would suggest that the clonidine-induced decrease in IOP may be mediated via a central mechanism. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Full text from SpringerLink