| Autor: |
Slaga TJ, Gleason GL, Hardin L |
| Jazyk: |
angličtina |
| Zdroj: |
Cancer letters [Cancer Lett] 1979 Jul; Vol. 7 (2-3), pp. 97-102. |
| DOI: |
10.1016/s0304-3835(79)80102-0 |
| Abstrakt: |
The abilities of 3-methylcholanthrene (3-MC) and 3,11-dimethylcholanthrene (3,11-DMC) to initiate skin tumors in Sencar mice were determined by using a 2-stage system of tumorigenesis. 3,11-DMC was found to have very weak skin tumor initiating activity when compared to the potent activity of 3-MC. The only difference between 3-MC and 3,11-DMC is the substitution of a methyl group in position 11 which is part of the 'K-region' or the 'peri' position. From these results, we suggest that an unhindered peri position adjacent to an angular benzene ring is necessary for carcinogenic activity of 3-MC. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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