Use of 5-fluorocytosine in patients with impaired renal function.
| Autor: | Dawborn JK, Page MD, Schiavone DJ |
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| Jazyk: | angličtina |
| Zdroj: | British medical journal [Br Med J] 1973 Nov 17; Vol. 4 (5889), pp. 382-4. |
| DOI: | 10.1136/bmj.4.5889.382 |
| Abstrakt: | The plasma level and elimination of 5-fluorocytosine (5-FC) was measured in normal subjects and patients with impaired renal function. Prolongation of the half-life of the drug in renal failure has been confirmed. Renal clearance of 5-FC was about 75% of the creatinine clearance and a corresponding modification of drug dosage should be made in patients with renal insufficiency. |
| Databáze: | MEDLINE |
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