| Autor: |
Ludden CT, Scriabine A, Ulm EH, Morgan G, Fisher MH, Ruyle WV |
| Jazyk: |
angličtina |
| Zdroj: |
Experientia [Experientia] 1979 Jun 15; Vol. 35 (6), pp. 799-801. |
| DOI: |
10.1007/BF01968258 |
| Abstrakt: |
3 novel pyridinylidene arylurea derivatives were found to lower arterial pressure in spontaneously hypertensive rats. Their relative oral potency ranged from 6 to 32 times that of guanethidine. The onset of antihypertensive action following their oral administration was less than 1 h and the duration of action ranged from 8 to over 24 h. The antihypertensive activity of the pyridinylidene arylureas was found to be assoicated with depletion of tissue catecholamines. Compound C depleted cardiac norepinephrine with little or no effect on total brain norepinephrine levels. It is suggested that compound C may have useful antihypertensive properties without CNS depressant activity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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