Phenotyping of South African black tuberculosis patients for inactivation of isoniazid.

Autor: Eidus L, Glatthaar E, Hodgkin MM, Nel EE, Kleeberg HH
Jazyk: angličtina
Zdroj: Research communications in chemical pathology and pharmacology [Res Commun Chem Pathol Pharmacol] 1979 Feb; Vol. 23 (2), pp. 243-56.
Abstrakt: Studies of isoniazid inactivation rates in black tuberculosis patients from South Africa and Birmingham, Alabama, showed a higher frequency of fast inactivation than those of North American Caucasian patients. After an oral test dose of 10 mg/kg isoniazid the percentage of fast inactivators in black patients of South Africa and Alabama was close to 60% while in North American white participants (Canadian and Birmingham Caucasians), the frequency of fast inactivation was approximately 40%.
Databáze: MEDLINE