Synthesis of a proposed thymic factor.

Autor: Strachan RG, Paleveda WJ Jr, Bergstrand SJ, Nutt RF, Holly FW, Veber DF
Jazyk: angličtina
Zdroj: Journal of medicinal chemistry [J Med Chem] 1979 May; Vol. 22 (5), pp. 586-8.
DOI: 10.1021/jm00191a026
Abstrakt: Less than Glu-Ala-Lys-Ser-Gln-Gly-Gly-Ser-Asn, a proposed serum thymic factor, has been synthesized. The protected precursor, less than Glu-Ala-Lys(i-Noc)-ser(Bzl)-Gln-Gly-Gly-Ser(Bzl)-Asn, was prepared by a combination of solid phase and solution methods. The benzyl blocking groups were removed by HF and the i-Noc blocking group was removed by catalytic hydrogenation.
Databáze: MEDLINE