| Autor: |
Cowley DJ, Dymock IW, Boyes BE, Wilson RY, Stagg BH, Lewin MR, Polak JM, Pearse AG |
| Jazyk: |
angličtina |
| Zdroj: |
Gut [Gut] 1973 Jan; Vol. 14 (1), pp. 25-9. |
| DOI: |
10.1136/gut.14.1.25 |
| Abstrakt: |
Some patients with the Zollinger-Ellison syndrome appear to have hypergastrinaemia and hyperplasia of the antral G cells but no tumour. This subgroup has been classified as Zollinger-Ellison syndrome type 1. We have treated such a patient by vagotomy and antrectomy, the fasting plasma gastrin and acid secretion subsequently returning to normal.A 17-year-old male had a four-year history of duodenal ulcer. Gastric secretion tests showed acid hypersecretion. Fasting plasma gastrin was 8350 pg/ml (normal 50-170 pg/ml). At laparotomy duodenal ulceration was confirmed but no pancreatic or other tumours were found. Truncal vagotomy and antrectomy was performed with distal pancreatectomy. Immunofluorescent staining showed hyperplasia of G cells in the resected antrum but a normal pancreas and duodenum. Six months after operation he was symptom free and acid secretion was reduced by 92%. The fasting plasma gastrin at two months was <50 pg/ml. These findings suggest that type 1 Zollinger-Ellison syndrome may be a clinical entity. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
