Short circuiting the ocular oxygen concentrating mechanism in the teleost Salmo gairdneri using carbonic anhydrase inhibitors.

Autor: Fairbanks MB, Hoffert JR, Fromm PO
Jazyk: angličtina
Zdroj: The Journal of general physiology [J Gen Physiol] 1974 Sep; Vol. 64 (3), pp. 263-73.
DOI: 10.1085/jgp.64.3.263
Abstrakt: Ocular oxygen concentration by the process of counter current multiplication in rainbow trout (Salmo gairdneri) was rapidly suppressed after intraperitoneal injections of the carbonic anhydrase inhibitor CL-11,366. The rapidity with which this drug acted suggested a short circuiting of the choroidal rete mirabile. A comparison was made between the time after injection of inhibitor at which oxygen concentrating ability was lost to the time after injection of inhibitor at which its presence in red blood cells, choroidal rete, pseudobranch, and retinal tissue was first noted. A scheme for the possible role of carbonic anhydrase from each of these tissues in the process of ocular oxygen concentration is given.
Databáze: MEDLINE