| Autor: |
Weiss E, Green AE, Grays R, Newman LM |
| Jazyk: |
angličtina |
| Zdroj: |
Infection and immunity [Infect Immun] 1973 Jul; Vol. 8 (1), pp. 4-7. |
| DOI: |
10.1128/iai.8.1.4-7.1973 |
| Abstrakt: |
The metabolism of Rickettsia tsutsugamushi (Gilliam strain) multiplying in irradiated L cells was investigated by methods involving the use of (14)C-labeled substrates and cycloheximide, an inhibitor of eukaryotic metabolism. Cycloheximide-resistant amino acid and adenine incorporations were appreciably higher in infected than in uninfected cultures during the period from 3 to 5 or 6 days postinoculation. The metabolism of R. rickettsi was similarly studied in primary duck embryo cells, which are more susceptible to infection with this rickettsia than are L cells. A difference in cycloheximide-resistant activity between infected and uninfected cultures was also noted, but was small. This finding is attributed to the more limited growth of R. rickettsi. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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