| Autor: |
Collins C, Laird RI, Richards PT, Starmer GA, Weyrauch S |
| Jazyk: |
angličtina |
| Zdroj: |
The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 1979 Sep; Vol. 31 (9), pp. 611-4. |
| DOI: |
10.1111/j.2042-7158.1979.tb13602.x |
| Abstrakt: |
Both aspirin at a high dose (400 mg kg-1) and caffeine (5 mg kg-1) induced hyperactivity in the DA rat, but lower doses of aspirin were without effect. Caffeine-induced hyperactivity was brief (2 h) but that due to aspirin was evident from 1--6 h after dosing. Co-administration of the two drugs caused long-lasting hyperactivity, even with doses of aspirin which had no stimulant effects themselves. Absorptive and metabolic effects did not appear to play a major role in the interaction. The most likely effect is that of salicylate on catecholamine utilization in the central nervous system, which is compounded in the presence of a phosphodiesterase inhibitor. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
Plný text