| Autor: |
Wenger WC, Murphy MP, Brierley GP, Altschuld RA |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of bioenergetics and biomembranes [J Bioenerg Biomembr] 1985 Oct; Vol. 17 (5), pp. 295-303. |
| DOI: |
10.1007/BF00751106 |
| Abstrakt: |
The concept that creatine phosphokinase is bound to the outer surface of the heart mitochondrial inner membrane originated from observations that the enzyme is retained by water-swollen heart mitochondria and by digitonin-treated heart mitochondria suspended in isotonic sucrose. The present study establishes that digitonin-treated mitochondria release creatine phosphokinase in isotonic KCl, and other investigators have reported an identical response for the water-swollen organelles. These observations suggest that mitochondrial creatine phosphokinase is not bound to the outer surface of the inner membrane at a site adjacent to the adenine nucleotide translocase under physiologic conditions. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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