| Autor: |
Ostanina LN, Dudnik IuV, Koz'mian LI |
| Jazyk: |
ruština |
| Zdroj: |
Antibiotiki [Antibiotiki] 1977 Jun; Vol. 22 (6), pp. 498-502. |
| Abstrakt: |
Beromycin, an antitumor anthracycline antibiotic formed in vitro complexes with native and denaturated DNA and ribosomal RNA. Beromycin had a comparatively low constant of DNA binding and to a less extent increased the melting temperature and viscosity of DNA than the other anthracycline antibiotics. A peculiar property of beromycin was very slow binding with DNA, the complex formation was completed in 60 minutes. Beromycin had a selective inhibitory effect on synthesis of nucleic acids in bacterial and tumor cells. Beromycin inhibited synthesis of RNA in the DNA-dependent RNA-polymerase reaction when both the native and denaturated DNA were used as the template. A lower biological activity of beromycin as compared to the other anthracycline antibiotics, such as rubomycin or carminomycin may be explained by lower affinity of this antibiotic to DNA. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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