[DNA repair system in nonspecific lung diseases].

Autor: Sil'vestrov VP, Moskaleva EIu, Iliushina NA, Martsinovskiĭ VIu, Il'in AV
Jazyk: ruština
Zdroj: Terapevticheskii arkhiv [Ter Arkh] 1985; Vol. 57 (7), pp. 114-6.
Abstrakt: It has been found that in 35-40% of patients with acute and chronic pneumonia, the reduced ability of peripheral blood lymphocytes for DNA repair is encountered 14 times as frequently as in normal subjects. After discontinuation of antibacterial therapy with penicillin or tetracycline antibiotics marked inhibition of the ability of lymphocytes for DNA repair is recorded. The tendency toward normalization of this characteristic occurs 1 week after discontinuation of antibiotic therapy for acute and 3 weeks for chronic pneumonia. The disorders of the ability of peripheral blood lymphocytes for DNA repair in the conditions under study are regarded as a possible cause of secondary immunodeficiency.
Databáze: MEDLINE