A device for irradiating guinea-pig skin with ultraviolet light.
| Autor: | Newmann EA, Parker RD |
|---|---|
| Jazyk: | angličtina |
| Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 1985 Jul; Vol. 23 (7), pp. 683-7. |
| DOI: | 10.1016/0278-6915(85)90157-7 |
| Abstrakt: | Animal methodology for investigating photosensitization is of interest because of the potential of some photodynamic chemicals to produce adverse skin reactions. A system has been developed that provides procedural flexibility and the ability to standardize individual guinea-pig exposures to ultraviolet light (UVA and UVB). It consists of a non-stressful restraining method that also protects the animals' eyes from the harmful effects of UV light while allowing reproducible exposure of the backs of the guinea-pigs. The procedure is described in detail and the qualitative and quantitative aspects of the system are presented. In addition, some quantitative aspects of the phototoxic variation in response to 8-methoxypsoralen are investigated. |
| Databáze: | MEDLINE |
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