| Autor: |
Case JL, Peyman GA, Barrada A, Hendricks R, Fiscella R, Hindi M |
| Jazyk: |
angličtina |
| Zdroj: |
Ophthalmic surgery [Ophthalmic Surg] 1985 Jun; Vol. 16 (6), pp. 378-81. |
| Abstrakt: |
The clearance of intravitreally administered 5-fluorouracil (5-FU) was studied under five experimental conditions. The same nontoxic dose resulted in similar initial intravitreal concentrations and cleared rapidly from all eyes (approximately 90% clearance within eight hours). Half-life values ranged from 46 to 168 minutes. The longest half-life occurred in aphakic-vitrectomized eyes in which hyaluronic acid (Healon) was substituted for vitreous (168 minutes). A similar half-life was found in normal eyes (150 minutes). The shortest half-life occurred in aphakic-vitrectomized eyes postoperatively (46 minutes). Intermediate half-life values occurred in vitrectomized but phakic eyes postoperatively (67 minutes) and in aphakic-vitrectomized "quiet" eyes (at least two weeks postoperatively) (82 minutes). |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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