Alterations in CFU-GM growth in preleukaemic and leukaemic AKR/J mice.

Autor: Alonso MC, Torres A, Solana R, Manzanares MR, Garcia-Castellano JM, Peña J
Jazyk: angličtina
Zdroj: Folia biologica [Folia Biol (Praha)] 1985; Vol. 31 (3), pp. 193-9.
Abstrakt: The behaviour of committed CFU-GM bone marrow cells was investigated in leukaemic and preleukaemic AKR/J mice. The number of bone marrow CFU-GM decreased in the leukaemic stage of spontaneous AKR/J leukaemia. The addition of AKR/J leukaemic cells inhibited CFU-GM growth from normal target bone marrow. The bone marrow CFU-GM growth was also reduced in late preleukaemic AKR/J mice, whereas no modification in the CFU-GM number in early preleukaemic animals was found.
Databáze: MEDLINE