| Autor: |
Evans JE, Browne TR, Kasdon DL, Szabo GK, Evans BA, Greenblatt DJ |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of clinical pharmacology [J Clin Pharmacol] 1985 May-Jun; Vol. 25 (4), pp. 309-12. |
| DOI: |
10.1002/j.1552-4604.1985.tb02846.x |
| Abstrakt: |
By infusing intravenously a series of different stable isotope labeled forms of a drug at different times prior to performing a single collection of a body fluid via puncture (or tissue via biopsy), one can obtain the same information about a drug's distribution as would be obtained by infusing a single dose of drug and performing serial collections of fluid (or tissue). Application of this technique of "staggered stable isotope administration" is illustrated with a study of entry of phenobarbital into the cerebrospinal fluid of a dog. Advantages and disadvantages of this technique are discussed. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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