| Autor: |
Wilf J, Gladner JA, Minton AP |
| Jazyk: |
angličtina |
| Zdroj: |
Thrombosis research [Thromb Res] 1985 Mar 15; Vol. 37 (6), pp. 681-8. |
| DOI: |
10.1016/0049-3848(85)90197-5 |
| Abstrakt: |
Addition of gamma-globulin, serum albumin, hemoglobin, or ovalbumin in concentrations of 1-10 g/dl to solutions of purified fibrinogen results in a substantial (up to six-fold) decrease in the lag time preceding appearance of a firm fibrin gel following addition of thrombin at 24 degrees C. The effect does not appear to be due to a protein-induced enhancement in the enzymatic activity of thrombin, nor does it appear to be due to the co-condensation of the added protein with fibrin/fibrinogen. It is suggested that the observed effect is primarily due to nonspecific volume exclusion arising from increased fractional occupancy of solution volume by macromolecules. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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