A novel multifrequency-tuned transceiver array for human-brain 31 P-MRSI at 7 T.

Autor: Li X; Center for Magnetic Resonance Research, Radiology Department, University of Minnesota, Minneapolis, Minnesota, USA., Zhu XH; Center for Magnetic Resonance Research, Radiology Department, University of Minnesota, Minneapolis, Minnesota, USA., Zhang XL; Department of Biomedical Engineering, Jacobs School of Medicine and Biomedical Sciences, School of Engineering and Applied Sciences, State University of New York at Buffalo, Buffalo, New York, USA., Waks M; Center for Magnetic Resonance Research, Radiology Department, University of Minnesota, Minneapolis, Minnesota, USA., Chen W; Center for Magnetic Resonance Research, Radiology Department, University of Minnesota, Minneapolis, Minnesota, USA.
Jazyk: angličtina
Zdroj: Magnetic resonance in medicine [Magn Reson Med] 2025 Feb 04. Date of Electronic Publication: 2025 Feb 04.
DOI: 10.1002/mrm.30449
Abstrakt: Purpose: Phosphorus-31 ( 31 P) MR spectroscopy imaging (MRSI) at 7 T is a powerful tool for investigating high-energy phosphate metabolism in human brains with significantly improved signal-to-noise ratio (SNR) and spectral resolution. However, this imaging technique requires dual-frequency radiofrequency coil for performing brain anatomical imaging and B 0 shimming at proton ( 1 H) operation frequency, and 31 P MRSI at lower operation frequency. Herein, we introduce a novel 31 P- 1 H dual-frequency radiofrequency coil design using a double-tuned and double-matched (DODO) coil that does not require complex circuitry or two coil layers and exhibits similar imaging performance as to single-frequency control coils for both 31 P and 1 H imaging operations.
Methods: We constructed an eight-element 31 P- 1 H dual-frequency DODO transceiver array and compared its performance with a quadrature-driven dual-tuned eight-element 31 P and eight-element 1 H transverse electromagnetic volume coil for both phantom and in vivo human-brain 31 P-MRSI studies at 7 T.
Results: The DODO transceiver array achieved high spatiotemporal resolution 31 P MRSI with 2.5-cc nominal voxel size and 22-min scan time covering the entire human brain, showing excellent SNR for mapping cerebral phosphorous metabolites such as phosphocreatine, adenosine triphosphate, and other low-concentration metabolites. Compared with the transverse electromagnetic volume coil, the DODO array demonstrated large improvements in 31 P-MRSI SNR in both phantom and human brain studies, with over 5-fold SNR gain in peripheral regions and over 2-fold SNR gain in central brain regions.
Conclusion: This simple and cost-effective array design and excellent performance can greatly benefit human-brain 31 P-MRSI applications at 7 T.
(© 2025 The Author(s). Magnetic Resonance in Medicine published by Wiley Periodicals LLC on behalf of International Society for Magnetic Resonance in Medicine.)
Databáze: MEDLINE
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