Oncocytic Carcinoma Ex-Pleomorphic Adenoma of the Lacrimal Gland.
| Autor: | Vahdani K; Adnexal Service, Moorfields Eye Hospital, London EC1V 2PD, United Kingdom., Rose GE |
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| Jazyk: | angličtina |
| Zdroj: | Ophthalmic plastic and reconstructive surgery [Ophthalmic Plast Reconstr Surg] 2025 Jan 06. Date of Electronic Publication: 2025 Jan 06. |
| DOI: | 10.1097/IOP.0000000000002894 |
| Abstrakt: | Oncocytic carcinoma is a rare malignant neoplasm of oncocytic cells, such cells being characterized by abundant granular eosinophilic cytoplasm, invasive growth, and pronounced cellular pleomorphism. It may arise de novo, or through malignant transformation of a pre-existing benign oncocytoma. Oncocytic carcinoma most commonly occurs in the salivary glands, with rare involvement of the ocular adnexa where it mainly affects caruncle, conjunctiva, and lacrimal sac, and only very arises in the lacrimal gland. This report presents a unique case of a 77-year-old male with lacrimal gland oncocytic carcinoma that probably arose from a pre-existing pleomorphic adenoma; local tumor control was achieved with local excision and adjuvant radiotherapy, but he developed metastasis and died 3 years later. Together with a literature review, this case underlines the aggressive biological behavior of lacrimal gland oncocytic carcinoma, with its high propensity for local and distant recurrence. Competing Interests: The authors have no financial or conflicts of interest to disclose. (Copyright © 2025 The American Society of Ophthalmic Plastic and Reconstructive Surgery, Inc.) |
| Databáze: | MEDLINE |
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