Unveiling the potential of pullulan in enhancing ketoprofen release from PHBV filaments.

Autor: de Carvalho LT; Chemical Engineering Department, Engineering School of Lorena, University of São Paulo, Lorena, São Paulo, Brazil; IMT Mines Albi, RAPSODEE UMR CNRS 5302, Albi, France., da Silva MB; Chemical Engineering Department, Engineering School of Lorena, University of São Paulo, Lorena, São Paulo, Brazil., Vieira TA; Chemical Engineering Department, Engineering School of Lorena, University of São Paulo, Lorena, São Paulo, Brazil., Maia LS; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, Brazil., de Macedo EF; Laboratory of Nanomaterials and Nanotoxicology, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, SP, Brazil., Tada DB; Laboratory of Nanomaterials and Nanotoxicology, Institute of Science and Technology, Federal University of São Paulo, São José dos Campos, SP, Brazil., Rosa DS; Center for Engineering, Modeling, and Applied Social Sciences (CECS), Federal University of ABC (UFABC), Santo André, Brazil., Mulinari DR; State University of Rio de Janeiro (UERJ), Department of Mechanical and Energy, Resende, RJ, Brazil. Electronic address: daniella.mulinari@fat.uerj.br., Medeiros SF; Chemical Engineering Department, Engineering School of Lorena, University of São Paulo, Lorena, São Paulo, Brazil. Electronic address: simonemedeiros@usp.br.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2025 Jan 02, pp. 139421. Date of Electronic Publication: 2025 Jan 02.
DOI: 10.1016/j.ijbiomac.2024.139421
Abstrakt: In this study, sustainable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) and pullulan (PUL)/PHBV filaments were prepared with ketoprofen for scaffold preparation. The research aimed evaluate the influence of pullulan in the filament properties, such as thermal, morphological, and biological behavior. Hansen parameters demonstrated the difference in the miscibility of the polymers and drug in the blend. This difference in solubility contributed to thermal stabilization, and reduced the crystallinity of the blend, observing a reduction in crystalline peak at 30.82° (002). The morphology change was observed by SEM images, in which ketoprofen appears to smooth and homogenize the filament surface. Cytotoxicity tests on osteoblast cells confirmed that all samples were biocompatible, and the presence of ketoprofen was comparable to the control group. Importantly, the in vitro release of ketoprofen revealed that the presence of pullulan increased the cumulative release of ketoprofen, from 0.1 % to 36 %, within 240 min of the dissolution test. This highlights the crucial role of pullulan in fine-tuning drug release. These findings underscore the potential of these materials for bone regeneration applications, combining the cytotoxic and cell adhesion properties of PHBV with the osteoblasts, and offering precise control over the degradation process and drug release through the incorporation of pullulan.
Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
(Copyright © 2024. Published by Elsevier B.V.)
Databáze: MEDLINE
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