Spontaneously regressing mass-like soft tissue involvement in a child with chronic non-bacterial osteomyelitis: case-based review.

Autor: Koru L; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Baysal B; Department of Radiology, Istanbul Medeniyet University, Istanbul, Turkey., Yıldırım ANT; Department of Pathology, Istanbul Medeniyet University, Istanbul, Turkey., Dizman EN; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Dursun HK; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Balci MO; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Kucuk E; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Kaya F; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Aydin Z; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Haslak F; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey., Ozturk K; Department of Pediatric Rheumatology, Istanbul Medeniyet University, Istanbul, Turkey. ozturk1209@gmail.com.
Jazyk: angličtina
Zdroj: Rheumatology international [Rheumatol Int] 2025 Jan 03; Vol. 45 (1), pp. 16. Date of Electronic Publication: 2025 Jan 03.
DOI: 10.1007/s00296-024-05768-1
Abstrakt: Chronic non-bacterial osteomyelitis (CNO) is an inflammatory bone disease, usually diagnosed in childhood. It is characterized by the presence of multifocal or unifocal osteolytic lesions that can cause bone pain and soft tissue swelling. CNO is known to have soft tissue involvement. However, soft tissue involvement large enough to give the appearance of a mass is rare. This article discusses a case of CNO with a mass-like appearance that involved soft tissue and spontaneously regressed, as well as presents CNO cases with soft tissue involvement and conducts a literature review on this subject. Our investigation revealed that edema and synovitis were the most frequently observed soft tissue involvements in association with CNO. Moreover, we also encountered myositis, a mass-like appearance, neuritis, and polyserositis within the surrounding muscles. Although, it is well known that bone inflammation tends to regress spontaneously in CNO patients which reflects the autoinflammatory nature of the disease, there is no such patient whose soft tissue involvement which has mass like appearance improved spontaneously. Therefore, we aimed to emphasize the clinical progress which can be easily underdiagnosed of CNO patients by the clinicians by presenting unique features of our patient and our detailed literature review.
Competing Interests: Declarations. Conflict of interest: All authors have read the manuscript and agreed with its content and stated that there is no conflict of interest. Ethical approval: All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent: Informed consent was obtained from patients and their legal guardians for publication. Declaration of non-publication: The authors declare that this manuscript has not been presented, published or submitted elsewhere, in whole or in part, in any language.
(© 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.)
Databáze: MEDLINE
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