Modeling synergy and individual effects of X-ray induced photodynamic therapy components.
| Autor: | Hossein FS; Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran., Naghavi N; Department of Electrical Engineering, Ferdowsi University of Mashhad, Mashhad, Iran. nn.naghavi@gmail.com., Sazgarnia A; Medical Physics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.; Department of Medical Physics, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran., Noghreiyan AV; Department of Medical Physics, Faculty of Medicine, University of Medical Sciences, Mashhad, Iran. |
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| Jazyk: | angličtina |
| Zdroj: | Scientific reports [Sci Rep] 2025 Jan 02; Vol. 15 (1), pp. 453. Date of Electronic Publication: 2025 Jan 02. |
| DOI: | 10.1038/s41598-024-84766-6 |
| Abstrakt: | X-ray induced photodynamic therapy (XPDT) utilizes self-lighting nanoparticles to combine the benefits of radiotherapy and photodynamic therapy. These nanomaterials transform X-ray to visible light that can be absorbed by nearby photosensitizers and in the presence of surrounding oxygen molecules generates reactive oxygen species, which are very toxic to the cells. Despite many studies conducted on modelling XPDT, little focused on the contribution of each component as well as their synergy effects. We developed a multiscale physicochemical model of XPDT to incorporate the key role of molecular oxygen in PDT component efficiency. Simultaneously, the effects of RT in the presence of TiO Competing Interests: Declarations. Competing interests: The authors declare no competing interests. (© 2024. The Author(s).) |
| Databáze: | MEDLINE |
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