The anticancer activity of fucoidan coated selenium nanoparticles and curcumin nanoparticles against colorectal cancer lines.

Autor: Alduais MA; Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia. malduais@ut.edu.sa.; Faculty of Science, Ibb University, Ibb, 70270, Yemen. malduais@ut.edu.sa., El Rabey HA; Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia.; Genetic Engineering and Biotechnology Research Institute, University of Sadat City, El-Sadat City, 32897, Egypt., Mohammed GM; Nutrition Department, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia., Al-Awthan YS; Faculty of Science, Ibb University, Ibb, 70270, Yemen.; Department of Biology, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia., Althiyabi AS; Biochemistry Department, Faculty of Science, University of Tabuk, Tabuk, 71491, Saudi Arabia., Attia ES; School of International Education, Hainan College of Economics and Business, Hainan, 571127, China.; National Nutrition Institute, Ministry of Health, Cairo, 4262114, Egypt., Rezk SM; Clinical Nutrition Department, Mahalla Hepatology Teaching Hospital, El-Mahalla El-Kubra, Gharbyia, Egypt., Tayel AA; Department of Fish Processing and Biotechnology, Faculty of Aquatic and Fisheries Sciences, Kafrelsheikh University, Kafrelsheikh, 33516, Egypt. ahmed_tayel@fsh.kfs.edu.eg.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2025 Jan 02; Vol. 15 (1), pp. 287. Date of Electronic Publication: 2025 Jan 02.
DOI: 10.1038/s41598-024-82687-y
Abstrakt: Cancers still globally endanger millions of people yearly; the incidences/mortalities of colorectal cancers are particularly increasing. The natural nanoparticles (NPs) and marine biopolymers were anticipated to provide effectual safe significances for managing cancers. The transformation of curcumin to nano-curcumin (NCur) was conducted with gum Arabic. The resulted NCur was utilized for the biosynthesis of selenium NPs (SeNPs), then bioactive nanocomposites (NC) from them with fucoidan (Fu) were fabricated and evaluated as candidates to suppress colorectal cancers (CaCo-2 and HT-29) cells. The NCur and NCur-synthesized SeNPs were effectually produced with mean diameters of 34.67 ± 4.32 and 5.17 ± 1.06 nm, respectively. The plain and NCs of Fu/NCur/SeNPs characterization, with infrared spectroscopy and electron microscopy, emphasized their interaction and conjugations. The entire agents/NCs had potent cytotoxic effects against cancers' lines; the NC of Fu/NCur/SeNPs was the most effectual with IC50 of 10.35 ± 0.83 and 19.44 ± 1.39 mg/L against CaCo-2 and HT-29 cells, respectively, which were significantly exceeded the action of standard cisplatin drug. The NCs led to vigorous DNA damages in CaCo-2 cancerous cells, as proved with comet assay. The ultrastructure imagining (scanning/transmission microscopy) of treated cells with Fu/NCur/SeNPs confirmed the capability of NCs to induce severe apoptosis and deformation signs in cancerous cells. The bio-based constituents of Fu/NCur/SeNPs and advocate their prospective applications for preventing/managing colorectal adenocarcinoma.
Competing Interests: Declarations. Competing interests: The authors declare no competing interests.
(© 2024. The Author(s).)
Databáze: MEDLINE
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