Suzuki-Miyaura/Mizoroki-Heck coupling cascade to access 2,2'-bifunctionalized biaryls.

Autor: Maurya NK; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India. malleswara.kuram@cdri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India., Singh A; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Sophisticated Analytical Instrument Facility & Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India. skshukla@cdri.res.in., Sahu A; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. vgrao@iitk.ac.in., Kumar A; Sophisticated Analytical Instrument Facility & Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India. skshukla@cdri.res.in., Kant R; Molecular and Structural Biology Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India., Rao VG; Department of Chemistry, Indian Institute of Technology Kanpur, Kanpur, Uttar Pradesh 208016, India. vgrao@iitk.ac.in., Shukla SK; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.; Sophisticated Analytical Instrument Facility & Research, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India. skshukla@cdri.res.in., Kuram MR; Medicinal & Process Chemistry Division, CSIR-Central Drug Research Institute, Lucknow, Uttar Pradesh 226031, India. malleswara.kuram@cdri.res.in.; Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, 201002, India.
Jazyk: angličtina
Zdroj: Chemical communications (Cambridge, England) [Chem Commun (Camb)] 2025 Jan 02. Date of Electronic Publication: 2025 Jan 02.
DOI: 10.1039/d4cc05763e
Abstrakt: Biaryl motifs are essential structural features in several drugs and functional molecules. Cyclic diaryliodonium has been scarcely explored as a bifunctional agent compared to ring opening and annulation reactions. Herein, a three-component cascade approach is developed to synthesize bifunctionalized biaryls employing cyclic diaryliodoniums as a biarylating agent. The mild conditions enabled a vast array of biarylated products in good yields in a single step. Furthermore, preliminary mechanistic details and photophysical properties have been investigated.
Databáze: MEDLINE
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