Improvement of image quality for small lesion sizes in 18 F-FDG prone breast silicon photomultiplier-based PET/CT imaging.

Autor: Yada N; Department of Radiology, Shimane University Hospital, Izumo, Japan., Kuroda H; Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Japan., Kawamura T; Division of Medical Informatics, Shimane University Hospital, Izumo, Japan., Fukuda M; Department of Radiology, Shimane University Hospital, Izumo, Japan., Miyahara Y; Department of Radiology, Shimane University Hospital, Izumo, Japan., Yoshizako T; Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Japan., Kaji Y; Department of Radiology, Faculty of Medicine, Shimane University, Izumo, Japan.
Jazyk: angličtina
Zdroj: Asia Oceania journal of nuclear medicine & biology [Asia Ocean J Nucl Med Biol] 2025; Vol. 13 (1), pp. 77-86.
DOI: 10.22038/aojnmb.2024.78080.1553
Abstrakt: Objectives: We investigated image quality and standardized uptake values (SUVs) for different lesion sizes using clinical data generated by 18 F-FDG-prone breast silicon photomultiplier (SiPM)-based positron emission tomography/computed tomography (PET/CT).
Methods: We evaluated the effect of point-spread function (PSF) modeling and Gaussian filtering (Gau) and determined the optimal reconstruction conditions. We compared the signal-to-noise ratio (SNR), contrast, %coefficient of variation (%CV), SUV, and Likert scale score between ordered-subset expectation maximization (OSEM) time-of-flight (TOF) and OSEM+TOF+PSF in phantom and clinical studies. The conventional image was generated with OSEM+TOF_Gau 6 mm. The National Electrical Manufacturers Association body phantom with 10-mm hot sphere data was acquired for 5 min. Twenty-six patients (40 lesions, ranging from 3.7 to 63.0 mm) were examined using prone breast PET/CT with a breast positioner for breast cancer staging. PET data were acquired 125±9.7 min after intravenous injection of 220±16.1 MBq at 5 min/bed.
Results: In the phantom study, a high SNR was obtained from a 3- to 5-mm Gaussian filter for OSEM+TOF+PSF. The contrast obtained with OSEM+TOF without Gaussian filtering was superior to that obtained with OSEM+TOF+PSF_Gau 4 mm. In the clinical study, the image quality depended on lesion size. The average SNR was significantly higher at 40.8% for lesions >20 mm with OSEM+TOF_Gau 6 mm than with OSEM+TOF without Gaussian filtering. The average contrast for lesions ≤10 mm was significantly higher by 42.0% with OSEM+TOF without Gaussian filtering than with OSEM+TOF_Gau 6 mm. The average SUV max of OSEM+TOF without Gaussian filtering significantly increased by 53.3% for lesions ≤10 mm.
Conclusion: OSEM+TOF without Gaussian filtering provided good contrast and quantitative value for small lesions.
Competing Interests: The authors declare that they have no conflict of interest.
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Databáze: MEDLINE
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