Maculopathies: A Systematic Literature Review on Pathophysiology, Public Health, and Treatment.
| Autor: | Pantelidou ME; Ophthalmology, James Paget University Hospital, Great Yarmouth, GBR., Sunnucks D; Barts and the London School of Medicine and Dentistry, Queen Mary University of London, London, GBR., Pantelidis EP; Ophthalmology, Ramsay Health Care, Mount Stuart Hospital, Torquay, GBR. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Dec 01; Vol. 16 (12), pp. e74911. Date of Electronic Publication: 2024 Dec 01 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.74911 |
| Abstrakt: | Macular degeneration (MD) is a pathological condition affecting the macula, an area located near the center of the retina. This disease affects individuals of all ages, both children and adults, causing severe visual impairment. Age-related macular degeneration (AMD) is the leading cause of visual loss in the older population while Stargardt disease (SD) is the most common hereditary maculopathy with an autosomal dominant pattern of inheritance. Current management involves anti-vascular endothelial growth factor intravitreal injections, visual aids, and other conservative prevention mechanisms that can only delay the inevitable progress of the disease. Macular dystrophies have an impact on both individuals and societies with psychological and financial implications, respectively. It is evident that vision impairment has a significant impact on patients' physical and mental well-being, and therefore it is important to improve current treatment modalities, develop stem cell therapies, and further novel treatments in order to provide a better prognosis and overall quality of life. Competing Interests: Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Pantelidou et al.) |
| Databáze: | MEDLINE |
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