Bromelia pinguin Extract Mitigates Glyphosate-Induced Toxicity in Human Cells.
| Autor: | Masías-Ambriz LO; Genotoxicology Laboratory, Universidad Autónoma de Occidente, Los Mochis, MEX., Caba-Flores MD; Biochemistry and Molecular Medicine, Universidad Autónoma de Nuevo León, Monterrey, MEX., Montes-Castro N; Biomedical Sciences, Universidad Autónoma de Occidente, Culiacán, MEX., García-Aguiar I; Biomedical Sciences, Universidad Autónoma de Occidente, Culiacán, MEX., Ruiz-Ramos R; Molecular Toxicology Laboratory, Universidad Veracruzana, Veracruz, MEX., Zenteno E; Biochemistry Laboratory, Universidad Nacional Autónoma de México, Ciudad de México, MEX., Martínez-Valenzuela C; Genotoxicology Laboratory, Universidad Autónoma de Occidente, Los Mochis, MEX. |
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| Jazyk: | angličtina |
| Zdroj: | Cureus [Cureus] 2024 Nov 28; Vol. 16 (11), pp. e74701. Date of Electronic Publication: 2024 Nov 28 (Print Publication: 2024). |
| DOI: | 10.7759/cureus.74701 |
| Abstrakt: | Introduction: Extensive agricultural activity results in significant exposure to pesticides, particularly glyphosate, which has been linked to immunological disorders, including apoptosis and inflammation. Bromelia pinguin , a species from the Bromeliaceaefamily native to Mexico, is traditionally used in folk medicine for its medicinal properties, including anti-inflammatory effects. This research aimed to evaluate the protective effects of Bromelia pinguin extract on human peripheral blood mononuclear cells (PBMCs) exposed to Faena®, a commercially available glyphosate-based herbicide. Methods: PBMCs were isolated from healthy donors. Cells were exposed to varying concentrations of glyphosate commercial formulation Faena®, pure potassium glyphosate salts, and Bromelia pinguin extract alone and in co-exposure studies with the extract. Dose-response curves were performed to determine IC Results: Exposure of PBMCs to glyphosate salts and Faena® resulted in a dose-dependent reduction of cell viability, with IC Conclusion: The extract of Bromelia pinguin can enhance cell viability and reduce the upregulation of inflammatory and apoptotic markers in human PBMCs exposed to glyphosate-based herbicides. These results provide new insights into the therapeutic potential of plant-based interventions in pesticide-induced immunological and inflammatory problems . Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. Bioethics Committee of the Universidad Autónoma de Occidente, Los Mochis, Sinaloa, Mexico issued approval 28.10/2021. Animal subjects: All authors have confirmed that this study did not involve animal subjects or tissue. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: Luis Omar Masías Ambriz was a recipient of a PhD fellowship from CONAHCYT, Mexico (CVU: 851487). MDC-F acknowledges the support of the Consejo Nacional de Humanidades, Ciencia y Tecnología, for the postdoctoral grant from the Estancias Posdoctorales por Mexico 2022(1) program. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Masías-Ambriz et al.) |
| Databáze: | MEDLINE |
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