Advances in research on the mechanism of tsRNA action in tumours.
| Autor: | Gao Y; The First People's Hospital of Changde City, Changde, Hunan, China., Huang Y; Hengyang Medical College, Hengyang, Hunan, China., Guo K; The First People's Hospital of Changde City, Changde, Hunan, China., Cheng J; The First People's Hospital of Changde City, Changde, Hunan, China., Luo Y; Hunan University of Arts and Science, Changde, Hunan, China., Deng Y; The First People's Hospital of Changde City, Changde, Hunan, China 285928388@csu.edu.cn 876264674@qq.com., Lei M; The First People's Hospital of Changde City, Changde, Hunan, China 285928388@csu.edu.cn 876264674@qq.com. |
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| Jazyk: | angličtina |
| Zdroj: | Journal of medical genetics [J Med Genet] 2024 Dec 31. Date of Electronic Publication: 2024 Dec 31. |
| DOI: | 10.1136/jmg-2024-110437 |
| Abstrakt: | tsRNA is a class of non-coding RNAs derived from mature or precursor tRNAs. In recent years, more and more studies have explored the correlation between tsRNAs and tumours. tsRNAs can affect the biological behaviours of tumour cells such as proliferation, apoptosis and metastasis by regulating gene expression, protein translation or post-transcriptional regulation. In this paper, we systematically review the production, biological function and research progress of tsRNA in tumour and discuss its prospects as biomarkers and therapeutic targets. Competing Interests: Competing interests: None declared. (© Author(s) (or their employer(s)) 2024. No commercial re-use. See rights and permissions. Published by BMJ Group.) |
| Databáze: | MEDLINE |
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