Human Riboviruses: A Comprehensive Study.

Autor: Mohan G; Department of Biological Sciences, Sri Venkateswara College, University of Delhi (South Campus), New Delhi, 110021, India., Choudhury A; Department of Biological Sciences, Sri Venkateswara College, University of Delhi (South Campus), New Delhi, 110021, India., Bhat J; Department of Biological Sciences, Sri Venkateswara College, University of Delhi (South Campus), New Delhi, 110021, India., Phartyal R; Department of Zoology, Sri Venkateswara College, University of Delhi (South Campus), New Delhi, 110021, India., Lal R; PhiXGen Private Limited, Gurugram, Haryana, 122001, India., Verma M; Department of Zoology, Hansraj College, University of Delhi, Mahatma Hansraj Marg, Malkaganj, Delhi, 110007, India. mansiverma@hrc.du.ac.in.
Jazyk: angličtina
Zdroj: Journal of molecular evolution [J Mol Evol] 2024 Dec 31. Date of Electronic Publication: 2024 Dec 31.
DOI: 10.1007/s00239-024-10221-9
Abstrakt: The urgency to understand the complex interactions between viruses, their animal reservoirs, and human populations has been necessitated by the continuous spread of zoonotic viral diseases as evidenced in epidemics and pandemics throughout human history. Riboviruses are involved in some of the most prevalent human diseases, responsible for causing epidemics and pandemics. These viruses have an animal origin and have been known to cross the inter-species barrier time and time again, eventually infecting human beings. Their evolution has been a long road to harbour important adaptations for increasing fitness, mutability and virulence; a result of natural selection and mutation pressure, making these viruses highly infectious and difficult to counter. Accumulating favourable mutations in the course, they imitate the GC content and codon usage patterns of the host for maximising the chances of infection. A myriad of viral and host factors determine the fate of specific viral infections, which may include virus protein and host receptor compatibility, host restriction factors and others. Thus, understanding the biology, transmission and molecular mechanisms of Riboviruses is essential for the development of effective antiviral treatments, vaccine development and strategies to prevent and control viral infections. Keeping these aspects in mind, this review aims to provide a holistic approach towards understanding Riboviruses.
Competing Interests: Declarations. Competing Interests: The authors declare that they have no competing interests. Ethical Approval: Not Applicable. Consent to Participate: Not Applicable. Consent for Publication: Not Applicable.
(© 2025. The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.)
Databáze: MEDLINE
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