Prevalence of Intersex/Differences in Sex Development and Primary Gonadal Insufficiency in a Pediatric Transgender Population.

Autor:	Randhawa H; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA., Knoll MM; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA., McPhaul M; Quest Diagnostics' Nichols Institute, San Juan Capistrano, California, USA., Dileepan K; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA., McDonough R; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.; Department of Medical Informatics, Children's Mercy Kansas City, Kansas City, Missouri, USA., Turpin A; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA., Jacobson JD; University of Missouri-Kansas City School of Medicine, Kansas City, Missouri, USA.; Division of Endocrinology and Diabetes, Department of Pediatrics, Children's Mercy Kansas City, Kansas City, Missouri, USA.
Jazyk:	angličtina
Zdroj:	Transgender health [Transgend Health] 2024 Dec 16; Vol. 9 (6), pp. 544-552. Date of Electronic Publication: 2024 Dec 16 (Print Publication: 2024).
DOI:	10.1089/trgh.2023.0033
Abstrakt:	Purpose: This study aims to assess the prevalence of intersex variations/differences in sex development (I/DSDs), associated adrenal conditions, and primary gonadal insufficiency in children with gender dysphoria. Methods: We performed a comprehensive review of the medical records for individuals who carried the diagnostic codes for gender dysphoria in addition to intersex and/or other conditions associated with sex steroid variations among patients evaluated by pediatric endocrinologists from 2013 to 2022. Results: We found that 9 of 612 (1.5%) transmasculine (TM) and 4 of 215 (1.9%) transfeminine patients had detectable I/DSDs. Although most patients were diagnosed with I/DSDs before evaluation of gender dysphoria, 4 of 13 (30.7%) were diagnosed with I/DSDs after being referred to endocrinology for gender dysphoria. In all cases, diagnoses were made by the endocrinologists evaluating for gender dysphoria. An additional 0.7% of TM patients were diagnosed with distinct hyperandrogenic adrenal conditions, and 1% of TM patients were diagnosed with primary ovarian insufficiency. Conclusion: The low, but clinically relevant, prevalence of I/DSDs, distinct adrenal conditions, and primary gonadal insufficiency in this transgender population supports the need for access to individualized expert medical care. Specifically, multidisciplinary clinics with experience in endocrinology may provide specialized support for the transgender community. (Copyright 2024, Mary Ann Liebert, Inc., publishers.)
Databáze:	MEDLINE
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