Late-Onset Idiopathic Generalized Epilepsy Manifesting With De Novo Late-Onset Absence Status Epilepticus After COVID-19 Infection: A Case Report.

Autor:	Otake M; Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN., Taniguchi G; Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN., Kato H; Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN., Fuji Y; Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN., Nakata C; Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN., Nakagawa E; Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN.
Jazyk:	angličtina
Zdroj:	Cureus [Cureus] 2024 Nov 27; Vol. 16 (11), pp. e74618. Date of Electronic Publication: 2024 Nov 27 (Print Publication: 2024).
DOI:	10.7759/cureus.74618
Abstrakt:	Herein, we present a case of idiopathic generalized epilepsy (IGE) manifesting as de novo late-onset absence status epilepticus (ASE) following mild coronavirus disease 2019 (COVID-19). A woman in her 40s presented with persistent 3-5.5 Hz generalized spike-wave complexes (SWCs) on electroencephalography (EEG). She experienced a generalized tonic-clonic seizure (GTCS) 10 days after the COVID-19 infection. She was diagnosed with epilepsy at 40 years of age, after which she was started on levetiracetam (LEV) 1,000 mg/day. After the medication was started, she experienced three other GTCSs. We performed a long-term video EEG of the patient, leading to a diagnosis of late-onset IGE with de novo late-onset ASE. She achieved seizure freedom for over a year with a combination of valproic acid (VPA) and lamotrigine (LTG), although her EEG continued to demonstrate persistent generalized SWCs. This case suggests that late-onset IGE accompanied by de novo late-onset status epilepticus may have been triggered by COVID-19. Persistent neuroinflammation may be reflected in persistent EEG abnormalities, even after epileptic seizures are well controlled with medications. LTG and VPA are believed to be effective for clinical management, and EEG is an essential modality for recording epileptic activity in outpatient settings. Competing Interests: Human subjects: Consent for treatment and open access publication was obtained or waived by all participants in this study. National Center Hospital, National Center of Neurology and Psychiatry, Japan issued approval A2024-065. This report has been approved by the Ethics Review Committee of National Center Hospital, National Center of Neurology and Psychiatry, Japan. Conflicts of interest: In compliance with the ICMJE uniform disclosure form, all authors declare the following: Payment/services info: All authors have declared that no financial support was received from any organization for the submitted work. Financial relationships: All authors have declared that they have no financial relationships at present or within the previous three years with any organizations that might have an interest in the submitted work. Other relationships: All authors have declared that there are no other relationships or activities that could appear to have influenced the submitted work. (Copyright © 2024, Otake et al.)
Databáze:	MEDLINE
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